Included are manuscripts, photographs, and related ephemeral items. The Archives provides an in-depth look at several areas of Bryan's life.

The Bryan Family History Collection contains items relating to both Mr. and Mrs. Bryan's families. The collection contains correspondence, photographs, diaries and an extensive genealogy. The Civil War, the Indian Wars, World War I and life in Haiti (1919-1921) are some of the subjects covered.

The Joseph M. Bryan Business Papers are especially important to the history of broadcasting and philanthropy. Items relating to Jefferson Standard Broadcasting provide access to historical material previously unavailable. The Bryan Business Papers also cover the benevolence of Mr. and Mrs. Bryan in many fields. Scholars can trace the progress of the Alzheimer's Disease research team as it seeks to identify the gene and chromosome that trigger the dreadful disease. The generosity shown toward educational programs is evident in the large amount of correspondence with local universities.